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triazoles and 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)-

triazoles has been researched along with 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)- in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (76.92)24.3611
2020's3 (23.08)2.80

Authors

AuthorsStudies
Altieri, M; Coleman, K; Crew, AP; Crews, CM; Dong, H; Hines, J; Lu, J; Qian, Y; Raina, K; Wang, J; Winkler, JD1
Apel, IJ; Asangani, IA; Chinnaiyan, AM; Dommeti, VL; Escara-Wilke, J; Feng, FY; Krishnamurthy, PM; Navone, NM; Plymate, SR; Wang, S; Wilder-Romans, K1
Gelato, KA; Haendler, B; Klingbeil, O; Lejeune, P; Lesche, R1
Altieri, DC; Halatsch, ME; Ishida, CT; Karpel-Massler, G; Shu, C; Siegelin, MD; Westhoff, MA1
Bianchetti, E; Halatsch, ME; Ishida, CT; Karpel-Massler, G; Shu, C; Siegelin, MD; Westhoff, MA1
Dang, CV; Fan, L; Fan, Y; Hu, X; Hu, Z; Huang, Q; Li, C; Montone, K; Pi, J; Shan, W; Tang, Z; Tanyi, JL; Wang, Y; Yang, L; Yuan, J; Zhang, L; Zhang, Y1
Bellini, E; Berchuck, A; Bernasocchi, T; Bertoni, F; Bielski, CM; Broaddus, RR; Carney, ME; Carr, SA; Cascione, L; Catapano, CV; Civenni, G; El Tekle, G; Enchev, RI; Garraway, LA; Janouskova, H; Kryukov, GV; Losa, M; Moch, H; Mutch, DG; Napoli, S; Peter, M; Rinaldi, A; Schraml, P; Svinkina, T; Theurillat, JP; Udeshi, ND; Ulbricht, A; Wild, PJ; Winterhoff, BJN1
Connelly, CJ; Greider, CW; Lee, SS; Pike, AM; Strong, MA; Wang, S1
DeCant, BT; Ebine, K; Kumar, K; Matsangou, M; Munshi, HG; Munshi, SZ; Pham, TND; Shang, M1
Bentrem, DJ; Kumar, K; Matsangou, M; Munshi, HG; Pham, TND; Shields, MA; Spaulding, C; Stempel, S1
Bodduluri, S; Lyv, X; Rowe, SM; Sanders, YY; Stanford, D; Thannickal, VJ; Xiang, Z; Zhou, QJ1
Alexander, G; Challagundla, KB; Chaturvedi, NK; Coulter, DW; Griggs, CN; Joshi, SS; Kling, MJ; McIntyre, EM; Ray, S1
Alexander, G; Challagundla, KB; Chaturvedi, NK; Coulter, DW; Joshi, SS; Kesherwani, V; Kling, MJ; McIntyre, EM; Mishra, NK; Ray, S1

Other Studies

13 other study(ies) available for triazoles and 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)-

ArticleYear
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.
    Chemistry & biology, 2015, Jun-18, Volume: 22, Issue:6

    Topics: Acetanilides; Adaptor Proteins, Signal Transducing; Apoptosis; Azepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Heterocyclic Compounds, 3-Ring; Humans; Nuclear Proteins; Peptide Hydrolases; Proto-Oncogene Proteins c-myc; Signal Transduction; Thalidomide; Transcription Factors; Triazoles; Ubiquitin-Protein Ligases

2015
BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer.
    Molecular cancer research : MCR, 2016, Volume: 14, Issue:4

    Topics: Acetanilides; Androgen Receptor Antagonists; Animals; Antineoplastic Combined Chemotherapy Protocols; Azepines; Benzamides; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Heterocyclic Compounds, 3-Ring; Humans; Male; Mice; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Signal Transduction; Triazoles; Xenograft Model Antitumor Assays

2016
Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents.
    Cell death & disease, 2016, 09-08, Volume: 7, Issue:9

    Topics: A549 Cells; Acetanilides; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Benzodiazepines; Carcinoma, Non-Small-Cell Lung; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Cycle; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Lung Neoplasms; Mice, SCID; Mutation; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Triazoles; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays

2016
Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma.
    Oncotarget, 2017, Jun-06, Volume: 8, Issue:23

    Topics: Acetanilides; Animals; Azepines; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Glioblastoma; Guanidines; Heat-Shock Proteins; Heterocyclic Compounds, 3-Ring; Humans; Lactams, Macrocyclic; Mice, Nude; Mitochondria; Mitochondrial Proteins; Molecular Chaperones; Proto-Oncogene Proteins c-myc; RNA Interference; Triazoles; Xenograft Model Antitumor Assays

2017
BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma.
    Oncotarget, 2017, May-02, Volume: 8, Issue:18

    Topics: Acetanilides; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Azepines; Bcl-2-Like Protein 11; Caspases; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synergism; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; Heterocyclic Compounds, 3-Ring; Humans; Membrane Potential, Mitochondrial; Mice; Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Sulfonamides; Triazoles; Xenograft Model Antitumor Assays

2017
Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition.
    Science translational medicine, 2017, 07-26, Volume: 9, Issue:400

    Topics: Acetanilides; Animals; Antineoplastic Agents; Azepines; Benzodiazepines; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Drug Synergism; Female; Heterocyclic Compounds, 3-Ring; Homologous Recombination; Humans; Ovarian Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Triazoles

2017
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.
    Nature medicine, 2017, Volume: 23, Issue:9

    Topics: Acetanilides; Adenocarcinoma, Clear Cell; Animals; Apoptosis; Azepines; Carcinoma, Endometrioid; Carcinosarcoma; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Cullin Proteins; Drug Resistance, Neoplasm; Endometrial Neoplasms; Epigenesis, Genetic; Female; Heterocyclic Compounds, 3-Ring; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Male; Mass Spectrometry; Mice, Nude; Molecular Targeted Therapy; Mutation; Neoplasm Transplantation; Neoplasms, Cystic, Mucinous, and Serous; Nuclear Proteins; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; Transcription Factors; Triazoles; Ubiquitination

2017
BRD4 inhibitors block telomere elongation.
    Nucleic acids research, 2017, Aug-21, Volume: 45, Issue:14

    Topics: Acetanilides; Animals; Azepines; Blotting, Southern; Cell Cycle Proteins; Cell Line; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; HeLa Cells; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; In Situ Hybridization, Fluorescence; Mice; Morpholines; Nuclear Proteins; Pyrones; RNA Interference; Telomerase; Telomere; Telomere Homeostasis; Telomere Shortening; Transcription Factors; Triazoles

2017
Induction of MNK Kinase-dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors.
    Molecular cancer therapeutics, 2019, Volume: 18, Issue:2

    Topics: Acetanilides; Aniline Compounds; Animals; Azepines; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Eukaryotic Initiation Factor-4E; Heterocyclic Compounds, 3-Ring; Humans; Mice; Phosphorylation; Protein Serine-Threonine Kinases; Purines; Signal Transduction; Thyroid Neoplasms; Triazoles; Xenograft Model Antitumor Assays

2019
Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1.
    International journal of molecular sciences, 2019, Sep-02, Volume: 20, Issue:17

    Topics: Acetanilides; Animals; Antineoplastic Agents; Azepines; Cell Line, Tumor; Female; Heterocyclic Compounds, 3-Ring; Heterogeneous Nuclear Ribonucleoprotein A1; Humans; Mice, Nude; Quercetin; Rats; Survivin; Triazoles

2019
Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.
    JCI insight, 2020, 07-23, Volume: 5, Issue:14

    Topics: Acetanilides; Aging; Animals; Azepines; Disease Models, Animal; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Histones; Humans; Lung; Mice; NADPH Oxidase 4; Nuclear Proteins; p300-CBP Transcription Factors; Pulmonary Fibrosis; Transcription Factors; Transforming Growth Factor beta1; Triazoles

2020
Synergistic efficacy of inhibiting MYCN and mTOR signaling against neuroblastoma.
    BMC cancer, 2021, Sep-26, Volume: 21, Issue:1

    Topics: Acetanilides; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Azepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Down-Regulation; Drug Synergism; Eukaryotic Initiation Factor-4E; G1 Phase Cell Cycle Checkpoints; Heterocyclic Compounds, 3-Ring; Humans; N-Myc Proto-Oncogene Protein; Neuroblastoma; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Spheroids, Cellular; TOR Serine-Threonine Kinases; Transcription Factors; Triazoles

2021
A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) Medulloblastoma.
    Journal of experimental & clinical cancer research : CR, 2022, Nov-11, Volume: 41, Issue:1

    Topics: Animals; Apoptosis; Azepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Epigenesis, Genetic; Histone Deacetylases; Humans; Medulloblastoma; Mice; Nuclear Proteins; Panobinostat; Proto-Oncogene Proteins c-myc; Transcription Factors; Triazoles

2022